MAD SCIENCE: Radical, Forbidden, and-or Dangerous scientific knowledge obsessively and recklessly ascertained by observation and experiment, recklessly tested, systematised and brought forth from the realm of Science Fiction and Fantasy.
Mad Science has long been rooted in Science Fiction so let us not forget those indomitable Mad Scientists who have dominated Literature, The Movies, and Television:

MAD SCIENCE & MAD SCIENTISTS RESEARCH:

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THE GALLERY OF MAD SCIENTISTS!

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LITERATURE & MOVIES...
Dr. Emmett Brown ......(Back to the Future from Universal Pictures)
Dr. Cavor ......(The First Men in the Moon by H.G. Wells)
Dr. Cyclops ......(Dr. Cyclops from Universal Pictures)
Dr. Evil ......(Austin Powers International Man of Mystery from New Line Cinema)
Dr. Frankenstein ......(Frankenstein by Mary Shelley)
Dr. Emilio Lizardo ......(The Adventures of Buckaroo Banzai-Across the 8th Dimension from MGM/UA)
Dr. Fu Manchu ......(The Mask of Dr. Fu Manchu from Universal Pictures)
Dr. George Wells? the Inventor ......(The Time Machine by H.G. Wells)
Dr. Griffin ......(The Invisible Man by H.G. Wells)
Dr. Jeckyll ......(The Strange Case of Dr. Jeckyll and Mr. Hyde by R.L. Stevenson)
Dr. Morbius ......(Forbidden Planet from Universal Pictures)
Dr. Moreau ......(The Island of Dr. Moreau by H.G. Wells)
Dr. Phibes ...... (The Abominable Dr. Phibes from American International Pictures)
Dr. Van Helsing ......(Dracula by Bram Stoker)
Dr. Wayne Zalinski ......(Honey I Shrunk the Kids from Walt Disney)
Dr. X ......(Dr. X from Warner Bros.)
Prof. Moriarty ......(Sherlock Holmes by Sir Arthur Conan Doyle)
Capt. Nemo ......(20,000 Leagues Under the Sea by Jules Verne)
Rotwang ......(Metropolis by Fritz Lang 1926)
Willy Wonka ......(Willy Wonka and the Chocolate Factory, based on Charlie and the Chocolate Factory by Roald Dahl)
COMIC BOOKS...
Dr. Spektor ......(The Occult Files of Doctor Spektor from Gold Key Comics)
Dr. Doom ......(The Fantastic Four from marvel Comics)
Dr. Octopus ......(Spiderman from Marvel Comics)
Brainiac ......(Superman from DC Comics)
Lex Luthor ......(Superman from DC Comics)
Mr. Freeze ......(Batman from DC Comics)
Mr. Monster ......(Mr. Monster from Dark Horse Comics)

TELEVISION...
Dr. Miguelito Loveless ......(The Wild Wild West 1960's-1970's)
Dexter, Boy Genius ......(Dexter's Laboratory from Cartoon Network)
Dr. Sam Beckett ......(Quantum Leap 1980's)
Dr. Shrinker ......(Dr. Shrinker serial on the Sid & Marty Krofft Super Show 1970's)
Dr. Who ......(Dr. Who BBC 1960's-1990's)
The Master ......(Dr. Who BBC 1960's-1990's)
Davros ......(Dr. Who BBC 1960's-1990's)
Dr. Cabot Rowland of Ultima Thule ......(SPACE 1999 "Death's other Dominion")
Dr. Dan Mateo of Moonbase Alpha ......(SPACE 1999 "Troubled Spirit")
Magus the Wizard ......(SPACE 1999 "New Adam, New Eve")
Mentor of Psychon ......(SPACE 1999 "The Metamorph")
Raan of Zenno ......(SPACE 1999 "Missing Link")
Quinn Mallory ......(Sliders)